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CIP SYSTEM

CIP STATION
Specification

  • Balance tank capacity

    150Liter

  • Valve operation

    Manual or Auto

  • Feeding Pump No.

    2

  • Temperature control

    Auto Control

  • Delivery Pressure

    2 bar

  • Heating

    Electric heater

  • CIP BALL

    Rotary Type

  • Conductivity Sensor

    0.2- 600

  • Delivery Flowrate (lpm)

    Max 60 LPM
Feature
BIOCANVAS SP — CIP System Technical Features

BIOCANVAS — CIP System Technical Features

High-efficiency Clean-In-Place (CIP) system based on advanced automation and hygienic design

Key Technical Features

  • High-purity Cleaning Water: Utilizes R/O (Reverse Osmosis) or chemically treated water for internal cleaning of vessels, tanks, and piping, minimizing impurities and microbial contamination.
  • Mobile Configuration: The MOBILE CIP unit is designed for portability, allowing shared use between multiple production lines or pilot systems while maximizing space efficiency.
  • Advanced Control Interface: A 10–15 inch touch HMI communicates with the PLC in real time, enabling intuitive control of pump speed, automatic valve operation, and temperature/pressure monitoring.
  • Recipe-based Cleaning Process: Predefined cleaning sequences (Pre-rinse → Alkaline Wash → Acid Rinse → Final Rinse) ensure reproducible results and reduce cleaning time.
  • Variable-speed Centrifugal Pump: The inverter-controlled pump allows flow and pressure adjustments, automatically optimizing flow rate per cleaning stage to improve energy efficiency.
  • HMI-centered Control: Displays real-time valve, pump, and sensor status, supports manual/automatic mode switching, and provides alarm log functionality.
  • Hygienic Pump Design: The centrifugal pump features a tool-free design for easy disassembly and reassembly. Wetted parts are made of SUS316L for enhanced chemical resistance.
  • Enhanced Drain Efficiency: The CIP tank bottom has a sloped design (>3°) for natural drainage with seamless weld finishing to prevent dead zones.
  • Return Line System: Directly connects to the vessel’s harvest port for closed-loop cleaning circulation, ensuring complete removal of residual contamination.
  • Simultaneous Cleaning Function: During CIP operation, cleaning solution circulates between the tank and vessel, and the spray nozzle inside the CIP tank cleans the interior simultaneously—no additional water supply required.
  • Real-time Data Logging: pH, temperature, flow, and pressure data are recorded via PLC for traceability and cleaning validation documentation.
  • Process Safety Design: Equipped with pressure relief valves and temperature sensors for automatic shutdown and alarm activation in case of overpressure or overheating.

Specification
CIP System — Technical Specification (Enhanced)

CIP System — Technical Specification

Enhanced Engineering Features for Models MC150M / MC150A / MC150AC

MC150 Series CIP (Clean-In-Place) systems are designed for hygienic cleaning of bioreactor and process piping with flexible control architecture. All models feature high-grade stainless-steel construction (SUS316L), low dead-volume piping, and are compatible with pharmaceutical-grade cleaning media. The system provides scalable automation—from manual to full automatic with heating and conductivity control—for diverse process environments.

Specification Table

ModelMC150MMC150AMC150AC
Balance Tank Capacity150 L (SUS316L, Electropolished)150 L (SUS316L, Electropolished)150 L (SUS316L, Electropolished)
Feeding PumpN/AN/A2 × Sanitary Centrifugal Pumps (VFD Control)
CIP BallRotary Spray Type (360° Coverage)Rotary Spray Type (360° Coverage)Rotary Spray Type (360° Coverage)
Number of Balance Tanks111
Delivery FlowrateMax 60 LPM @ 2 barMax 60 LPM @ 2 barMax 60 LPM @ 2 bar
Valve OperationManual Butterfly ValvesAutomatic Pneumatic ValvesAutomatic Pneumatic Valves (PLC Integrated)
Delivery Pressure 2 bar (Adjustable) 2 bar (Adjustable) 2 bar (Adjustable, Closed-loop Feedback)
Temperature Control Manual Rinse Semi-Auto Monitoring Fully Automatic PID Temperature Control
Delivery Temperature Ambient Ambient Ambient to 60°C (±1°C)
Temperature Sensor N/A RTD (PT100) RTD (PT100, PLC-linked)
Heating System N/A N/A Electric Heater (Stainless Enclosure, Safety Cutoff)
Conductivity Sensor N/A N/A 0.2–600 µS/cm, 4–20 mA Output, PLC Feedback
Control System Manual Panel PLC (Semi-Auto Mode) PLC + HMI Touch Screen (Full Automation)
Material of Construction SUS316L (Inner Ra ≤ 0.6 µm) SUS316L (Inner Ra ≤ 0.6 µm) SUS316L (Inner Ra ≤ 0.6 µm)
Utility Requirements Power: 220V / Air: N/A Power: 220V / Air: 0.5 MPa Power: 220V / Air: 0.5 MPa
Optional Features Manual Operation Only Recipe Storage, Valve Auto Control Data Logging, Trend Graph, Alarm History
All specifications subject to change according to process requirements and validation standards.

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Application
MC150 Series CIP System — Application Fields

MC150 Series CIP (Clean-In-Place) System

Application fields for hygienic cleaning processes across industries

Application Fields

Biopharmaceutical Processes

Applied in tank and pipeline cleaning for vaccine, protein drug, and cell culture production lines that require aseptic environments. Provides automated cleaning cycles compliant with GMP standards.

Fermentation and Cultivation Systems

Used to remove internal contamination and prevent cross-contamination in microbial and cell culture equipment. The system integrates with DO and pH control systems for efficient cleaning.

Food and Beverage Industry

Ideal for hygienic cleaning of probiotic, enzyme, dairy, and beverage lines. Recipe-based cleaning cycles ensure consistency and reproducibility of quality.

Chemical and Advanced Materials Industry

Used for internal cleaning of equipment in high-purity chemical, coating, and additive production processes, preventing product contamination and improving production efficiency.

Medical Device and Sanitary Equipment

Ensures reliable sterile cleaning for medical washing systems, cell therapy production equipment, and biocontainers requiring validated cleaning protocols.

Pilot and Research Facilities

In laboratories and pilot-scale facilities where frequent process changes occur, the automatic CIP system shortens cleaning time and enhances experimental reproducibility.

© CENTRION BIOPROCESS — MC150 Series Application Guide