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Bioreactors I Fermenters

BIOTWINstation
Specification

  • Display

    15inch Wide Touch TFT LCD

  • Agitation RPM

    10 ~ 1500rpm

  • Motor drive

    AC Servo Motor, BLDC Motor

  • Sensor

    Basic (Temp, pH, DO, Anti Foam, ORP) Optional(OD, O2, CO2, MFC, MFM)

  • Controller Type

    Two-vessel operation available

  • Power Requirements

    AC110~220V, 50/60Hz

  • Max. Noise Level

    <55dB(A)

  • Fuse protection

    15A

  • Weight

    20Kg
Feature
BIOCANVAS Lab Fermenter / Bioreactor — Features & Specifications

BIOTWINstation   Lab Fermenter l Bioreactor

Key Features

  • - Twin Controller System : Independent dual control for two fermenters simultaneously with one system.
  • - Large 20” Monitor: Wide display for intuitive monitoring, multi-window operation, and real-time visualization of all
      process     parameters.
  • - Easy Calibration : Simple calibration of pH, DO, temperature, and bubble detection sensors.
  • - Compact & Space-Saving Design : Ideal for laboratory environments, optimized for various small-scale culture experiments.
  • - Multi-Purpose Application : Supports microbial and cell culture processes with flexible configuration.
  • - Flexible Vessel Options : Volumes from 250 mL to 15 L in multiple designs (single wall, single round, bowl, double jacket).
  • - External Device Connectivity : Compatible with O₂/CO₂ analyzers, gas mixers, scales, level sensors, external pumps, and
      analog printers.
  • - Real-Time Process Recording : Self-diagnosis system with process recording and real-time control.
  • - Centralized Data Management : Multi-channel network system for integrated data control through a single PC.
  • - Easy Cleaning & Maintenance : Fermenter ports and vessels designed for quick installation and efficient cleaning.

Technical Specifications

CategorySpecification
Control SystemTwin Controller for two Vessel
15” Wide Monitor for multi-window visualization
MICOM-based control for stability and reliability
Data & MonitoringReal-time data recording and process control
USB backup
Multi-channel PC network management
Agitation SystemTop Drive: Low-speed, stable, quiet (ideal for cell culture)
Bottom Drive: Magnetic drive, contamination-free (ideal for microbial fermentation)
Process ControlDO Cascade (automatic dissolved oxygen control)
Supports DO-stat, pH-stat, exponential feeding strategies
Vessel Options250 mL to 15 L capacity
Available in Single Wall, Single Round, Bowl, or Double Jacket design
External IntegrationO₂/CO₂ Analyzer, Gas Mixer, Scale, Level Sensor, External Pump, Analog Printer, etc.
StructureCompact footprint for laboratories
Open port configuration for easy installation and cleaning
MaterialsSUS316L stainless steel
Precision-machined parts, corrosion-resistant, high durability
Specification
BIOCANVAS Lab Fermenter / Bioreactor — Technical Specifications

BIOTWINstation   Lab Fermenter l Bioreactor

Specification

CategorySpecification
Display15-inch Wide Touch TFT LCD
Agitation Speed Range10 ~ 1500 rpm
Motor DriveAC Servo Motor, BLDC Motor
Maximum Noise Range< 55 dB(A)
Ambient ConditionsAmbient Temp 0~50℃, Humidity ≤85% RH
Electrical SpecAC 110~220V, 50/60Hz, Single Phase, 500W (Free Voltage)
Fuse Capacity15A
Weight20 kg

Control System

CategorySpecification
TypeBuilt-in PC Control SCADA System
Voltage Specification90~260V, 50/60Hz, Free Voltage
SMPS ModuleBuilt-in UL Certified SMPS Module
Motor ControlPWM frequency control for AC Servo, AC Induction, BLDC Motor — smooth acceleration/deceleration
Communication PortsRS232 x2, RS422 or RS485
Analog I/OAnalog Input: 12 points, Output: 4 points, Record: 12 points
Control ParametersTemperature, pH, DO Cascade, Foam, ORP, OD, O₂, CO₂, Agitation, MFC, Pressure, Balancer Control

Feed Control Mode

CategorySpecification
ModeFed-Batch Culture by DO, pH Interlock Pump Control
Feeding Pump6 Built-in Feeding Pumps (Boxer or Watson-Marlow), 2 External Pumps

Communication & Data Logging

CategorySpecification
Communication PortEthernet — 1 PC connects up to 8 controllers
PC ControlData logging, trend graphs, process control (PID, limit values, cascade, feed programs)
Record OutputEach sensor output selectable — D-SUB 25-pin Female Type; USB Excel file export
USB StorageMeasured data and setup configurations stored automatically

Feeding Pump

CategorySpecification
Pump6 built-in pumps, 2 external (optional)
Motor TypeAC Motor or DC Motor, minimum speed 10 rpm
Speed Range0~70 rpm
Resolution10 rpm
Control ModeProgrammable PID Feeding Control; assignable for Acid, Base, Antifoam, Feed
Video
Download
Application
BIOTWIN — Applications

BIOTWIN — Applications

From microbes to mammalian cells: scalable solutions for modern bioprocessing

Application Areas

The BIOTWIN supports diverse bioprocesses with flexible hardware and advanced automation. Below are the primary application domains and example use cases.

Microbial Fermentation

Cultivation of bacteria, yeast, and fungi for research and scale-up, with precise pH/DO and temperature control.

E. coliYeastFungi

Cell Culture

Low-shear mixing for mammalian, insect, and plant cells; compatible with serum-free and perfusion strategies.

CHOHEK293Sf9

High-Density Fermentation

Advanced feeding modes (DO-stat, pH-stat, exponential) to maximize titer and productivity with tight control loops.

Fed-batchDO-statpH-stat

Biopharmaceutical Production

Process development and scale-up for vaccines, therapeutic proteins, and monoclonal antibodies.

mAbsVaccinesRecombinant

Food & Nutraceuticals

Production of probiotics, enzymes, vitamins, and functional ingredients with hygienic design.

ProbioticsEnzymesVitamins

Industrial Biotechnology

Bio-based chemicals, biofuels, and sustainable materials enabled by robust control and aeration capacity.

BiofuelsBiochemicalsSustainability

Process Development & Scale-Up

Seamless transition from lab to pilot/industrial scale with consistent geometry and automation philosophy.

QbDPATScale-up
Application — Culture Methods by Nutrient Supply Type

Culture Methods by Nutrient Supply Type

Culture Methods Overview

Batch Culture

In a batch culture, a fixed amount of nutrients is initially provided in the culture medium. As the culture progresses, the nutrients are gradually consumed, and the cells eventually reach a stationary phase. This is the most common and basic culture method.

Fed-Batch Culture

Fed-batch culture is designed to enhance cell density and product yield compared to batch culture. In this method, additional nutrients are periodically or continuously added during cultivation, making it suitable for productivity improvement.

Continuous Culture

In continuous culture, fresh medium is continuously supplied while an equal volume of culture is simultaneously withdrawn. This maintains cells in a steady growth phase, allowing for stable and consistent production conditions.

Perfusion Culture

Perfusion culture allows for high-density and long-term cell cultivation. The medium is continuously perfused to supply nutrients and remove waste products, ensuring stable productivity and optimal cell growth.