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Bioreactors I Fermenters

BIOCANVAS SP Series
Specification

  • Vessel Volume

    30L~1,000L

  • Agitation

    AC Motor Top or Bottom Drive (Mechanical seal/Magnetic Coupling) 30~1,000rpm

  • Materials & Finish

    Vessel/Piping : SUS316L,SUS304(Elecrolytic polishing)

  • Sterilization

    Heat exchanger or inject steam into jacket.(105℃~130℃)

  • Aeration

    Sparger : Ring sparger(SUS 316L) * Filter : Inlet(0.2㎛), Outlet filter(0.2㎛)

  • Sensor

    pH,DO,Temp,Anti-Foam, Pressure Control, etc.

  • Controller

    20” Touch Screen Color LCD, PLC system

  • Data Storage

    pH, DO, Temperature,Foam, Pressure and Agitation speed

Feature
BIOCANVAS SP – Pilot Scale Fermenter / Bioreactor

BIOCANVAS SP – Pilot Scale Fermenter / Bioreactor

Overview

BIOCANVAS SP is a pilot-scale fermenter and bioreactor optimized for R&D and scale-up applications. With intelligent automation, flexible agitation systems, and GMP-compliant quality design, it delivers optimal performance across a wide range of bioprocesses, from microbial fermentation to cell culture.

Key Features

🔹 Optimized for Pilot-Scale Fermentation

Designed to accommodate various fermentation applications, enabling efficient use in research, development, and scale-up processes.

🔹 Automation and User-Friendly Design

A fully automated system with an intuitive user interface ensures easy operation for all users while minimizing experimental errors and losses.

🔹 Flexible Agitation System

  • Top Drive: Low-speed, low-noise design ideal for cell culture
  • Bottom Drive: Magnetic coupling system optimized for high-efficiency microbial fermentation

🔹 Automatic Sterilization and Temperature Control

Equipped with an automatic sterilization unit for convenient cleaning and precise temperature control according to preset parameters.

🔹 Easy Maintenance

The open-frame structure allows easy access for valve and piping operations. The head-lift system makes vessel cleaning and maintenance more convenient.

Advanced Control System

  • 20-inch Intelligent Wide Touchscreen Controller
  • PLC-based SCADA System ensures industrial-grade stability and reliability
  • Multi-Sensor Board enables real-time diagnostics and rapid issue identification

Data Management

  • Automatic storage of setpoints, real-time data, and PID control states (internal memory and USB supported)
  • Integrated PC software for data logging and remote monitoring

Fermentation Process Control

  • High-density fermentation control: DO-stat, pH-stat, Exponential Feeding
  • Automatic DO Cascade Control
  • Flow rate and mass control
  • Integration with external devices such as biosensors, gas analyzers, pumps, and mixers

Hygienic and Safe Design

Constructed from precision-machined SUS316L stainless steel components to ensure excellent corrosion resistance, safety, and airtight performance.
Stainless steel transfer piping enhances sterility and ease of operation.

Regulatory and Quality Compliance

Complies with cGMP-level IQ/OQ standards, making it suitable for use in GMP production environments.

© 2025 CENTRION Co., Ltd. All rights reserved.

Specification
CENTRION Fermenter / Bioreactor Specification

Fermenter l Bioreactor Specification 

 30–1000 L · PLC Automatic Control

1) Vessel Specification

ItemValue
Total Capacity (L)30, 50, 70, 100, 150, 300, 500, 1000
Working Volume (L)21, 35, 50, 70, 100, 210, 350, 700
Aspect Ratio (H/D)2:1 (Customizable on request)
MaterialSUS 316L / 304 (Electrolytic Polishing)
Surface Roughness (Ra)Inner 0.6–0.8 μm / Outer 1.2 μm
Sight GlassOblong Type
SUS316L
PID Control
PLC System

2) Agitation System

ItemDescription
DriveAC Gear Motor / AC Servo Motor
ControlAutomatic Agitation Speed Control (PID)
ImpellersRushton / Marine / Foam Breaker (SUS316L)
SealMechanical Seal / Magnetic Coupling
Agitation TypeTop Drive or Bottom Drive

3) Process Control

Control ItemRange & Method
pH2.0–14.0 / Gel Type Electrode / PID Control
DO0–200% or 0–20ppm / Polarographic / PID Control
TemperatureAmbient +3℃–80℃ / RTD (Pt-100) / PID Control
PressureManual or Automatic Back Pressure Control

4) Main Control

ItemDescription
Panel17" Touch Screen Color LCD
ProcessorPLC System
ProgramAuto Sterilization / Fermentation / Valve Control
Data LoggingpH, DO, Pressure, Temperature, Agitation Speed
CommunicationRS-232C (USB, Printer, PC)

5) Sterilization & Aeration

ItemDescription
Sterilization MethodHeat Exchanger / Jacket Steam (105–130℃)
SpargerRing Type (SUS316L)
FilterInlet 0.2 μm / Outlet 0.2 μm

6) Port Configuration

  • Exhaust Port, Pressure Gauge, Pressure Transmitter, Foam Sensor
  • Septum Port, Inoculum Port, Sampling, pH/DO/Temp Ports
  • Aeration, Bypass, Rupture Disk, Harvest Line

7) Notes

  • Specifications are subject to change according to customer requirements.
  • Options: CIP System, Gas Mixing, Remote Monitoring, Data Backup
© CENTRION BIOPROCESS
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Application
BIOCANVAS SP — Applications

BIOCANVAS SP — Applications

From microbes to mammalian cells: scalable solutions for modern bioprocessing

Application Areas

The BIOCANVAS SP supports diverse bioprocesses with flexible hardware and advanced automation. Below are the primary application domains and example use cases.

Microbial Fermentation

Cultivation of bacteria, yeast, and fungi for research and scale-up, with precise pH/DO and temperature control.

E. coliYeastFungi

Cell Culture

Low-shear mixing for mammalian, insect, and plant cells; compatible with serum-free and perfusion strategies.

CHOHEK293Sf9

High-Density Fermentation

Advanced feeding modes (DO-stat, pH-stat, exponential) to maximize titer and productivity with tight control loops.

Fed-batchDO-statpH-stat

Biopharmaceutical Production

Process development and scale-up for vaccines, therapeutic proteins, and monoclonal antibodies.

mAbsVaccinesRecombinant

Food & Nutraceuticals

Production of probiotics, enzymes, vitamins, and functional ingredients with hygienic design.

ProbioticsEnzymesVitamins

Industrial Biotechnology

Bio-based chemicals, biofuels, and sustainable materials enabled by robust control and aeration capacity.

BiofuelsBiochemicalsSustainability

Process Development & Scale-Up

Seamless transition from lab to pilot/industrial scale with consistent geometry and automation philosophy.

QbDPATScale-up